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The Hofmann rearrangement is a process whereby aromatic amides produced from acids or acid halides react with bromine or chlorine solutions in sodium hydroxide to produce amines.
When acyl chlorides and sodium azide are combined to form aromatic acyl azides, isocyanates are produced via a process known as Curtius rearrangement. When water is added to the aryl amines, the isocyanates hydrolyze, releasing carbon dioxide.
Through the use of imidoyl chloride, aromatic amides are transformed into amidines (normally by reaction with PCl5 or POCl3). An aryl amide, amine, and phosphorus chloride are heated together in the traditional method using an innocuous solvent such chloroform or benzene.
The Global aromatic amide market accounted for $XX Billion in 2021 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2024 to 2030.
The synthetic community is very interested in visible-light photoredox catalysis. As a result, the activation mode may offer a more reliable and effective platform for the activation of organic molecules, opening the door to the development of numerous mildly adducted controlled radical processes.
The prevalence of this structural motif in several natural compounds, medicines, and functionalized materials has led to an increasing interest in amide synthesis using the photoredox catalysis method in this context.
By using this method, a variety of amides can be successfully made from halides, arenes, and even alkanes when exposed to visible light.
These procedures offer a reliable substitute for well-known methods for the synthesis of amides that include condensation between a carboxylic acid and an amine, which is facilitated by a stoichiometric activating agent.
Visible-light-driven photoredox catalysis has evolved into one of the most potent tools in organic synthesis thanks to its exceptional participation in the disciplines of photochemistry and radical chemistry. Visible-light-driven photoredox catalysis has been widely used in recent years to create a variety of structurally different amides.