Aptamers are brief, single-stranded DNA or RNA molecules (ssDNA or ssRNA) that can attach to a variety of targets, such as proteins, peptides, carbohydrates, tiny compounds, poisons, and even living cells. Due to their propensity to form helices and single-stranded loops, aptamers can take on a wide range of configurations.
Aptamers and antibodies have many applications in common, however the nucleic acid-based structure of aptamers, which are predominantly oligonucleotides, differs greatly from the amino acid-based structure of antibodies, which are proteins. Aptamers may be a better choice than antibodies for various applications because of this distinction.
Aptamers, particularly RNA strands, degrade quickly in biological conditions due to interactions with biomolecules. To disintegrate in blood in as little as a few minutes, which is considerably too short for most medicinal purposes.
A composite material is made up of two components that have distinct physical and chemical properties. When they are mixed, they form a material that is specialised to perform a specific function, such as becoming stronger, lighter, or electrically resistant.
The Global Composite Aptamer Market accounted for $XX Billion in 2022 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2023 to 2030.
Aptamer-functionalized metal-organic framework-based electrospun nanofibrous composite coating fibre for specific recognition of ultratrace microcystin in water.
It was suggested to use electrospinning, metal-organic frameworks (MOF) seed development, and aptamer AuNPs UiO-66-NH2 electrospun nanofibrous coated fibre for the specific identification of microcystin-LR (MC-LR).
Investigations into the obtained affinity nanofibrous coating fibre’s shape, structure, and stability were conducted. By combining solid-phase microextraction (SPME) with LC-MS, it was possible to successfully produce high loading of MOFs and aptamers on the nanofibrous fibre for precise identification of MC-LR.
Extremely low LOD, good precision, and low relative error were used to produce highly specific recognition of MC-LR with little interference from analogues, which was superior to that of the conventional SPME or SPE protocols.
In samples of raw pond water, reinforced tap water, and river water, MC-LR recoveries were satisfactory. This demonstrated a desirable alternate access to precise recognition and extremely sensitive analysis of MC-LR in water.
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