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By deducting the solvent contribution in a balanced capillary bridge, the novel method of differential viscometry determines the specific viscosity of a solution in an exact and precise manner. The design of a viscosity detector used in size-exclusion chromatography is modified in the current work to incorporate the differential viscometer principle.
The size and conformation of all varieties of synthetic polymers, biopolymers, proteins, and peptides can be determined using this analytical detector, which is a highly sensitive, online differential viscometer that can be utilised as a component of a triple detector GPC/SEC system.
Compared to any viscometer now on the market, it can significantly lower noise and boost sensitivity by more than an order of magnitude.It is now routinely possible to identify substances with lower molecular weights and at lower concentrations using the detector at far lower flow rates than was previously feasible. Applications for semi-micro GPC/SEC chromatography will gain from this novel detector.
By monitoring the differential pressure across a capillary tube kept at a constant temperature, the accurate viscosity measurement of a viscometer is determined. Immersing the measuring capillary in a tiny, stirred heated oil bath allows for precise temperature control.
A single capillary tube can be modified to handle the wide range of viscosity measurements needed by various products thanks to the viscometer’s ability to accommodate a wide range of pressures and temperatures at the inlet and return sample directly to the process.
Operation is made simple by a widescreen graphical user interface and software that offers a variety of auto validation, calibration, and in-built diagnostic tools. Alarms are displayed on screens and can be classified as active or inactive.
The Global Differential Viscometer market accounted for $XX Billion in 2021 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2023 to 2030.
A Wheatstone bridge arrangement is employed is made up of four fluidic resistances of equal value. The differential pressure is initially equal to zero because the bridge is balanced. The resistance value of the fluidic resistances in the lower branch and the first resistance in the upper branch are changed by a polymer peak entering the bridge.
This resistance remains unchanged since the peak is postponed in a sizable reservoir volume that is situated before the last resistance in the upper branch. The resulting shift in differential pressure serves as a direct indicator of the fluidic resistance’s fluidic viscosity. For symmetry-related reasons, a delay volume is inserted in the lower branch.
A commercial viscosity detector also uses this idea. This device cannot directly be integrated with micromachined separation systems because it is designed for use with standard polymer chromatography systems. As a result, a different micromachined design utilising the Wheatstone bridge configuration was created.
