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Electrochemical biosensors provide an attractive means to analyse the content of a biological sample due to the direct conversion of a biological event to an electronic signal.
Due to their high sensitivity and selectivity, quick reaction times, and low cost, electrochemical sensors utilising nanoparticles have emerged as one of the most suited technologies for the detection of analytes of interest in clinical chemistry.
Nanosensors are mechanical or chemical sensors that can be used to measure physical parameters like temperature or to detect the presence of chemical species and nanoparticles. Nanosensors can find the tiny particles because of their nanoscale size.
The Global Electrochemical nanosensor market accounted for $XX Billion in 2022 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2023 to 2030.
Development of Electrochemical Nanosensor for the Detection of Malaria Parasite in Clinical Samples.Medical diagnostics and biological disease monitoring in the clinical laboratory are significant because they aid in the detection of numerous diseases or the start of several diseases.
The use of markers has been the mainstay in identifying and quantifying target compounds in biological fluids. Most diseases are detected using sophisticated procedures, which are costly and time-consuming.
The development of sensitive, selective, accurate, quick, and cost-effective approaches for clinical diagnosis has recently been a key focus of researchers.
Because of its high sensitivity and selectivity, short reaction time, and low cost, electrochemical sensors based on nanoparticles have emerged as one of the most suited technologies for the detection of analytes of interest in clinical chemistry.
Malaria is a complex, infectious hematologic disease caused by the protozoan parasite Plasmodium falciparum. The parasite lives in humans for part of its life and in Anopheles mosquitoes for the rest. Malaria is spread to humans by infected Anopheles mosquitoes.
The malaria parasite needs iron to develop because numerous enzymes in the parasite’s metabolic pathways require iron. Clinical signs of malaria appear at the intra-erythrocytic stage. Along with oxygen, haemoglobin breakdown leads to the release of free heme or iron protoporphyrin IX (FePPIX).
Because free heme is hazardous to the parasite, P. falciparum transforms reactive heme species into hemozoin, a compact, highly insoluble, weakly magnetic crystal with reduced pro-oxidant capacity that is harmless to the parasite.
