EPLERENONE MARKET

INTRODUCTION

Eplerenone, marketed under the trade name Inspira, is a potassium-saving diuretic that acts as an aldosterone antagonist and is used to treat chronic heart failure and high blood pressure, especially in people who have resistant hypertension brought on by increased aldosterone.

It treats heart failure and lowers the chance of developing other heart issues or a stroke. It also aids in preventing the progression of heart failure. Hyperaldosteronism is a condition that it can occasionally be used to cure. When the body produces too much aldosterone, a hormone that regulates blood pressure, this occurs. Long-term treatment with eplerenone is possible.

EPLERENONE MARKET SIZE AND FORECAST

The Global EPLERENONE market accounted for $XX Billion in 2023 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2024 to 2030.

EPLERENONE MARKET RECENT DEVELOPMENT

In response to advice from the trial's independent Executive Steering Committee, Pfizer Inc. declared that it intends to stop recruiting participants early in the EMPHASIS-HF trial.

The recommendations come after a second interim analysis by the EMPHASIS-HF trial's independent Data Safety Monitoring Committee, which confirmed the study's primary effectiveness endpoint had been attained early in accordance with the protocol's pre-defined stopping procedures.

In comparison to patients on the placebo arm of the trial, who received standard care along with a matching placebo, the interim analysis revealed that patients treated with INSPRA® (eplerenone), in addition to current standard of care, had a significantly lower risk of cardiovascular (CV) death or heart failure (HF) hospitalization.

The trial's placebo arm, where patients received standard care along with a matching placebo, saw a significant increase in the risk of cardiovascular (CV) death or heart failure (HF) hospitalization, according to the interim analysis.

Patients treated with INSPRA® (eplerenone), in addition to standard care, did not experience this risk. Eplerenone was generally well tolerated during the EMPHASIS-HF study, according to the interim analysis performed by the independent data safety monitoring committee.

Both hyperkalemia (elevated potassium) (8 percent in the eplerenone group vs 3% in the placebo group; p 0.001) and renal impairment (4 percent in the eplerenone group vs 2% in the placebo group; p 0.05) were listed as adverse events. Agents that act as mineralocorticoid receptor antagonists frequently cause these negative effects

. In the double-blind, placebo-controlled, parallel group EMPHASIS-HF trial, patients with mild chronic systolic heart failure (NYHA functional Class II) and left ventricular systolic dysfunction were compared between eplerenone plus standard heart failure therapy and placebo plus standard heart failure therapy.

EPLERENONE MARKET COMPANY PROFILE

• Pfizer
• NCBI
• Alport Syndrome
• Medicover
• Sino Biopharm, Inc

THIS EPLERENONE MARKET REPORT WILL ANSWER FOLLOWING QUESTIONS

1. How many EPLERENONE are manufactured per annum globally? Who are the sub-component suppliers in different regions?
2. Cost breakup of a Global EPLERENONE and key vendor selection criteria
3. Where is the EPLERENONE manufactured? What is the average margin per unit?
4. Market share of Global EPLERENONE market manufacturers and their upcoming products
5. Cost advantage for OEMs who manufacture Global EPLERENONE in-house
6. key predictions for next 5 years in Global EPLERENONE market
7. Average B-2-B EPLERENONE market price in all segments
8. Latest trends in EPLERENONE market, by every market segment
9. The market size (both volume and value) of the EPLERENONE market in 2024-2030 and every year in between?
10. Production breakup of EPLERENONE market, by suppliers and their OEM relationship