The substance polyethylene glycol (PEG) has applications in both industry and medicine. Industrially, PEG compounds are used in cosmetic products as surfactants, emulsifiers, cleaning agents, humectants, and skin conditioners because many of them are hydrophilic.PEG is a medicine that belongs to the laxative class.
FDA-approved indications include the treatment of constipation in patients. PEG is chosen over other medicines for treating chronic constipation and diarrhoea because it has fewer side effects and a better flavour profile. Since there is no salt absorption, PEG laxatives are safer than PEG electrolyte lavage solutions.
PEGs are made up of many catalysed ethylene glycol monomer units and come in a range of molecular weights.PEG is a medicine that is little absorbed in the digestive tract and is soluble in water.PEG joins water molecules by hydrogen bonds.Because of this, it can prevent water from being reabsorbed, which causes water retention in the stool and raises osmotic pressure.
The stool softens as a result, and bowel movements become more frequent.When PEG is administered orally, common adverse effects include gas, nausea, cramping in the stomach, diarrhoea, a bloated abdomen, and rectal bleeding.
Following topical application, urticaria has been reported after using PEG electrolyte lavage solution.With the recurrent topical skin exposure of PEG in burn patients as well as the intravenous administration of medications using PEG.
The Global EV Polyethylene glycol (PEG) coolant Market accounted for $XX Billion in 2022 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2023 to 2030.
PEG poisoning is extremely rare, and exposure to it is unusual. PEG with a high or intermediate molecular weight is thought to be harmless since oral consumption results in quite limited absorption.Application of low-weight PEG products is associated with metabolic acidosis and kidney damage.
PEG overdoses in patients can produce diarrhoea, which could potentially result in dehydration, especially if water consumption is low.The outcome of dehydration may then be confusion and even seizures.In the event of a PEG overdose, there is no antidote.It is possible to buy polyethylene glycol over the counter.
As a result, the medicine is now more widely available. Healthcare professionals must stress usage and abuse instructions. Patients should receive advice on when to stop using PEG as well as when the drug will start to take effect.
Ethylene oxide, the primary component of antifreeze, is polymerized via a ring-opening method to create PEG, which enables the creation of PEGs with a variety of molecular weights and molecular weight distributions. Its suitability for a variety of uses is due to the range of weights it offers.
PEG has numerous features that make it unique, even though changing its molecular weight can have a modest impact on some of them, mostly on its form and physical appearance. It is non-volatile, inert, colourless, inert, and non-toxic. It is also very soluble in organic solvents like benzene, carbon tetrachloride, and chloroform as well as water.
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