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A pH nanosensor is a miniature device capable of measuring the acidity or alkalinity of a substance. It is a powerful and versatile tool for monitoring the environment, in particular for detecting changes in water quality or for the detection of pollutants.
The pH nanosensor is composed of two components: a nanoelectrode and a nanosensing element. The nanoelectrode is a tiny electrode, usually made from a conductive material, such as gold or platinum.
It is sensitive enough to detect even tiny changes in the acidity or alkalinity of a substance. The nanosensing element is a small, sensitive device that is capable of detecting very small changes in electrical current or voltage.
The pH nanosensor is used to measure the pH of a solution, which is a measure of the acidity or alkalinity of the solution.
The pH nanosensor can be used to detect changes in pH in a wide range of applications, such as in water quality monitoring, food and beverage processing, and medical diagnostics.
The pH nanosensor is an important tool for studying and monitoring the environment, as it can quickly detect small changes in the acidity or alkalinity of a substance.
This ability can be used to identify potential pollutants and other contaminants in the environment. In addition, the pH nanosensor has the potential to be used in the development of new medical treatments and diagnostics.
Overall, the pH nanosensor is a powerful and versatile tool for monitoring the environment and detecting pollutants. Its small size and sensitivity make it an ideal tool for a wide range of applications.
The Global pH Nanosensor market accounted for $XX Billion in 2022 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2023 to 2030.
Intracellular pH (pHi), which is a measure of a wide range of processes including vesicle trafficking, cellular metabolism, proliferation, and apoptosis, among others, is essential in regulating how cells function.
The new pH nanosensor is expected to be a highly valuable label-free analytical tool for investigating pathological conditions characterised by cell pH misregulation, without any constraint on the type of targeted cells.
With a hydrogen ion receptor on its membrane-based ion-selective electrode, the indication electrode offered an ideal selectivity for intracellular measurements. The pH nanosensor’s analytical properties showed a linear response range, a quick response time (<5 s), a suitable medium-term drift (0.7 mV h–1), and a Nernstian response with appropriate repeatability and reproducibility.
Surface-enhanced Raman scattering and other spectroscopic measurements are the main analytical methods available for determining pHi. A portfolio of other methods also includes these methods.
The primary drawbacks of these methods are that they frequently call for substantial cell manipulation and that signal intensity is hard to measure using straightforward assays and is affected by a number of experimental parameters, including dye localization, photobleaching, and quenching, especially in fluorescence studies.
By comparison, the electrode tip required for measurements in electrochemical sensing can be reduced to nanoscale dimensions (nanotips), providing a label-free method of detecting pH. High spatial resolution continuous signals are also provided by this method in real-time.
In the potentiometric measurements, the pH nanosensor served as the indication electrode (WE). To characterise the pH nanosensor response, batch studies were conducted using a commercial Ag/AgCl reference electrode (REcom) as the reference electrode for potentiometry readout.
Traditionally, non-redox active ions are measured using potentiometry, which uses a two-electrode system (an indicator and a reference electrode). Redox-active ions and biomolecules are often measured using voltammetry/amperometry, which uses a three-electrode system.
The earliest known pHi measurements, which were based on glass microelectrodes with an internal liquid contact and relatively large tip dimensions and a slow response time due to the electrode’s configuration.
