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When a volatile organic compound (VOC) and nitrogen oxide mix, a molecule called a photochemical oxidant is created. They fall under the category of harmful air pollutants. Oxygen peroxide, peroxyacetyl nitrate, and ozone are a few examples of photochemical oxidants.
These substances are dangerous air pollutants and the essential constituents needed for the smog-forming process. Photochemical oxidants are often physical or chemical pollutants that have the potential to cause serious health issues. These contaminants might be results of corrosion processes, including rust or particle debris.
When handling or creating dangerous photochemical oxidants, there are stringent industrial regulations in place to prevent mishaps.
When pollutant-forming emissions are present, a phenomena known as photochemical oxidant production (also known as photochemical smog) takes place.
In the presence of sunshine, low humidity, nitrogen oxides, and volatile organic compounds (VOCs, except methane), it is most frequent in relatively stagnant air. Ethane, ethylene, benzene, acetone, and formaldehyde are some examples of VOCs.
Photochemical oxidation harms some materials (such plastic and rubber) and crops while also causing breathing difficulties and eye discomfort.
The Photochemical Oxidation accounted for $XX Billion in 2022 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2023 to 2030.
Protein structure and protein-protein interactions are investigated using the hydroxyl radical protein footprinting technique known as “in vivo fast photochemical oxidation of proteins” (IV-FPOP).
Mass spectrometry (MS) is used to examine proteins that have undergone oxidative modification by IV-FPOP, and label-free MS is used to measure the degree of oxidation.
Due to differences in solvent accessibility, peptide oxidation alterations provide important information regarding protein structure. However, the larger sample size required for animal investigations increases the amount of time needed for instrumentation and sample processing.
The combined application of IV-FPOP and the improved multiplexing approach coupled precursor isotopic labeling and isobaric tagging (cPILOT) for a higher-throughput study of oxidative changes in C. elegans is described. There were noticeable variations between label-free MS and cPILOT in terms of performance.
Among all known potential FPOP changes, the addition of oxygen (+16) was the modification that was found to be the most prevalent. In order to boost the throughput of research looking at oxidative protein changes, this work introduces IV-FPOP along with improved multiplexing technologies like cPILOT.
