Four metal rods that are parallel make create the quadrupole. A radio frequency voltage with a DC offset voltage is applied between each pair of opposing rods after electrically connecting one pair to the other. Ions move between the rods of the quadrupole.
At a given ratio of voltages, only ions with a specific mass-to-charge ratio will pass through the detector; all other ions will crash with the rods due to their unstable trajectories. By continually changing the applied voltage, this enables the operator to select an ion with a certain m/z or to scan for a range of m/z values.
The Mathieu differential equation can be used to model this mathematically. Although hyperbolic rods are preferred, cylindrical rods with a specified ratio of rod diameter to spacing offer an appropriate approximation to hyperbolas that is easier to fabricate. Resolution and peak shape are greatly affected by even small changes in the ratio.
In order to fine-tune operational characteristics in light of anticipated application requirements, several manufacturers make somewhat varied ratio choices.A triple quadrupole mass spectrometer is a linear array of three quadrupoles. The middle quadrupole serves as a collision cell while the first and third quadrupoles serve as mass filters.
This collision cell is an RF-only quadrupole that uses Ar, He, or N2 gas to cause the dissociation of a chosen parent ion from Q1 in the event of a collision. Following fragments are sent to Q3, where they can be thoroughly scanned or filtered. Using this procedure, pieces that can be studied for tandem mass spectrometric structural elucidation are made possible.
As an illustration, the Q1 might be configured to “filter” for a medication ion with known mass that is fragmented in the Q2. The intensity of the pieces can then be determined by setting the third quadrupole to scan the entire m/z range.
The Global Quadrupole mass spectrometer market accounted for $XX Billion in 2022 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2023 to 2030.
New LC/MS and GC/MS quadrupole mass spectrometers were launched by Agilent Technologies Inc. and will be on display at the 70th ASMS Conference on Mass Spectrometry and Associated Subjects, taking place June 5–9, 2022 in Minneapolis, Minnesota.
In Agilent’s more than 50-year history of mass spectrometry, the 6475 triple quadrupole LC/MS system, 5977C GC/MSD, 7000E GC/TQ, and 7010C GC/TQ represent the most recent revolution. The new LC/TQ and GC/TQ solutions have instrument intelligence built-in to streamline lab procedures.
Customers may overcome significant performance hurdles with hydrogen carrier gas with the help of the new GC/SQ and GC/TQ devices with the HydroInert source.
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