When bacteria come in contact with biomaterial surfaces, unattached cationic antibiotics are transferred from the surfaces of the biomaterials to the bacteria. Based on this fresh idea, anionic microgels filled with cationic small-molecule antibiotics were created.
Bacterial interaction, not that made by macrophages or osteoblasts, was what caused the release of antibiotics. Biocompatibility and the antibacterial trait were thus guaranteed.
The Global Smart Bacteria-Responsive Drug Delivery System market accounted for $XX Billion in 2022 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2023 to 2030.
Growing bacterial infection risk has sparked widespread worry with the quick development of implantable biomaterials.
The standard therapies for peri-implant infections are insufficient to address the demand due to the high rate of bacterial infections returning and the problem of drug resistance.
In this context, stimuli-responsive biomaterials have drawn interest due to their tremendous potential to autonomously modify the drug release rate.
Therefore, a variety of intelligent bacteria-responsive drug delivery systems (DDSs) have been developed to autonomously release antibacterial agents from the implants at the infected sites in a temporal and spatial way.
They provided an overview of recent developments in bacteria-responsive DDSs for bacterial infections, primarily in terms of the various trigger mechanisms, such as physical stimuli-responsive, virulence-factor-responsive, host-immune-response-responsive, and their combinations.
The next wave of common antibacterial treatments is anticipated to include DDSs that respond to smart bacteria.Despite the fact that some biomaterials have antibacterial properties, most antibacterial action is carried out by drug delivery systems.
Drug loading in conventional DDSs typically involves directly introducing sizable antibiotics into the matrix or attaching them to surfaces using covalent bonds.
The sudden release of drugs, which is known for its cytotoxicity, may be triggered by physically drug-loaded DDSs, though.
In the meantime, the covalently drug-loaded DDSs restrict the antimicrobial effects to the system surfaces due to the properties of covalent bonds. Additionally, a frequent issue with conventional DDSs is that they cannot be given immediately.
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