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Titania Nanoplate is an innovative, groundbreaking material developed by the Japanese company NANOCHEM, Inc. It is an ultra-thin ceramic plate composed of titania nanoparticles, which are among the most abundant minerals on Earth. It is highly durable, lightweight, and flexible, making it an ideal material for a variety of applications.
Titania Nanoplate is composed of titania nanoparticles, which are finely divided particles of the mineral titanium dioxide. These particles are incredibly small, measuring just a few nanometers in diameter. This makes them incredibly lightweight and flexible, yet still incredibly strong and durable. This makes them ideal for use in a variety of applications, such as medical implants, aerospace components, electrical components, and more.
The unique composition of Titania Nanoplate also allows it to be easily manipulated in a variety of ways. The plate can be cut to custom sizes, curved and bent to create unique shapes, or even printed with intricate patterns to create unique designs. This makes Titania Nanoplate an incredibly versatile material, with countless potential applications.
In addition to its many practical uses, Titania Nanoplate also has many environmental benefits. The plate is recycled easily and is completely biodegradable, making it an incredibly sustainable material. This makes it an ideal material for use in green building projects and other environmentally friendly initiatives.
The Global Titania Nanoplate market accounted for $XX Billion in 2022 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2023 to 2030.
To enhance anticancer therapeutic benefits, the development of effective nanomedicines is very appealing. These heterostructures, known as Au NPL@TiO2 heterostructures, are titania-coated Au nanoplates that serve as both nanoagents and synergistic photothermal/sonodynamic treatment infrared (NIR) windows.
A high photothermal conversion efficiency of 42.05% when irradiated by a 1064 nm laser is possessed by the as-prepared Au NPL@TiO2 nanostructures, which are expected to be very promising candidates as photothermal agents because of the controlled TiO2 shells, which also give the nanostructures a red shift to the NIR II region.
Conversely, following activation by ultrasonic (US) via a sonodynamic process, the Au nanoplates (Au NPLs), acting as electron traps, significantly enhance the formation of reactive oxygen species (ROS) by the Au NPL@TiO2 nanostructures as opposed to pure TiO2 shell nanoparticles.
Additionally, a reasonably comprehensive in vitro evaluation of the toxicity and therapeutic efficacy of the Au NPL@TiO2 nanostructures was conducted. The Au NPL@TiO2 nanostructures are hazardous in a laser power density-dependent manner and produce a significant amount of ROS within cells, ultimately leading to the death of cancer cells.
Moreover, modest concentrations of the Au NPL@TiO2 nanostructures demonstrated a synergistic therapeutic effect, with a cell survival of just 20.3% during both photothermal and sonodynamic activation.
The complete removal of tumours in mouse experiments further demonstrates the effectiveness of the PTT and SDT combination. This work paves the door for the application of novel nanoagents for advanced multifunctional anticancer therapeutics in the second NIR window, namely, two-dimensional (2D) gold nanoplate core/TiO2 shell nanostructures.
