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Aptamers can be used to recognise a target’s molecular structure. A successful use of aptamers includes the identification of pathogens, cancer, the detection of environmental contaminants, and stem cell markers.
An aptamer is a single-stranded nucleic acid oligomer composed of either RNA or DNA that has a high affinity and selectivity for binding to a particular target molecule.
Short, single-stranded oligonucleotides called aptamers bind to particular target molecules. Single-stranded oligonucleotides’ ability to take on different shapes results in high affinity and outstanding specificity for targets. Aptamers can therefore be utilised as antibodies’ analogues.
Aptamers are 3D-folded structures of single-stranded oligonucleotides with lengths ranging from 20 to 60 bases that were chosen in vitro using the systematic evolution of ligand exponential enrichment (SELEX) technique.
The Global Aptamer Sensor Market accounted for $XX Billion in 2023 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2024 to 2030.
Recent progress on electrochemical (bio)sensors based on aptamer-molecularly imprinted polymer dual recognition. Due to their superior antigen specificity and affinity, antibodies have been the most common receptors utilised to build biosensors and bioassays. Antibodies, despite having various uses, have many disadvantages, including expensive pricing, poor stability, limited availability, and strict storage requirements.
Due to their similar selectivity to natural equivalents, precise conformational and binding relationships to analytes, and synthetic receptors that can replace antibodies in biosensors and bioassays, aptamers and molecularly imprinted polymers (MIPs) have gained popularity.
A hybrid system that combines aptamers and MIPs has been developed more recently to detect a variety of analytes, such as small molecules, proteins, and viruses, by combining their complementary strengths and desirable features. This study concentrates on the most recent developments in electrochemical (bio)sensors based on aptamer-MIP (AptaMIP) dual receptors because of their overall low cost, high sensitivity, compatibility with miniaturisation, and portability.
AptaMIP-based electrochemical sensors have three design strategies: aptamer incorporated in MIP as a hybrid receptor, aptamer and MIP dual-functional areas-based microfluidic device, and MIP/Target/aptamer sandwich assay. Sensor setups, transducing processes, strengths, and limits are explored for each technique.
