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ChIP-Seq determines the binding sites of DNA-associated proteins and can be used to identify global binding sites for a specific protein. Crosslinking of DNA-protein complexes is usually the first step in ChIP-Seq. After fragmentation, samples are processed with an exonuclease to trim unbound oligonucleotides.
A laboratory procedure for determining the exact sequence (order) of the four building units, or bases, that comprise DNA. DNA stores information in a code created by arranging the four bases (designated by the letters A, C, G, and T) in different orders.
DNA chip technology employs small arrays (microarrays) of molecules immobilised on solid surfaces for biochemical investigation.
The Global DNA sequencing chip market accounted for $XX Billion in 2023 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2024 to 2030.
A hybrid separation process provides 600 bases in 6.5 minutes for ultrafast DNA sequencing on a microchip. The availability of a high-accuracy human genome sequence offers scientists and clinical researchers a useful tool for determining the root causes of genetically based disorders and generating new treatments and cures.
Because determining the complete sequence of a human-sized genome costs two orders of magnitude more, projects like the National Institutes of Health’s Cancer Genome Atlas Project must reduce sequencing costs by two orders of magnitude.
Significant breakthroughs in sequencing technology, akin to the invention of capillary array electrophoresis (CAE), are necessary to allow for the required cost reductions for future genome sequencing programmes. The separation medium was changed from cross-linked gels to linear polymer solutions when switching from slab gels to capillaries.
Although pDMA has been investigated as an effective sequencing matrix in CAE instruments, it has not been used for sequencing in microchip devices. An M13 standard was sequenced in entangled pDMA matrices at 3-5% (wt/vol) concentration in pHEA-coated microchips, and raw fluorescence data were analysed by the NNIM basecaller.
Both the average read length and However, all previous LPA matrices used for microchip sequencing resulted in significantly longer separation times.
