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It is proved that a tiny fibre optical nanomechanical probe (FONP) can be utilised to monitor in vivo tissue and determine the mechanical characteristics of individual cells.
The FONP is created utilising femtosecond laser 3D printing to programme a microcantilever probe on the end face of a single-mode fibre. Structure-correlated mechanics is used to offer a method of tailoring the microcantilever’s spring constant to the sample, and FONP’s stiffness can be changed.
The greatest microforce sensitivity and detection limit of the FONPs, which operate in air and liquids and exhibit ultra-high force resolution, are respectively.
The FONPs significantly advance the realisation of fundamental biological discoveries by offering a common methodology for directly programming fibre-optic AFMs.
To undertake delicate biomechanical measurements and disclose the complex mechanical environment of biological processes, ultrasensitive nanomechanical tools, such as atomic force microscopy (AFM), can be used.
The Global fibre optic nanomechanical probe (FONP) market accounted for $XX Billion in 2022 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2023 to 2030.
A portable fibre optical nanomechanical probe (FONP) was created by fibre sensing researchers at Shenzhen University to measure the biomechanical characteristics of tissue and even individual cells in vivo.
The in vivo biomechanical properties of tissue, single cells, and other soft biomaterials can be measured with this high-precision mechanical sensor device. The results might have a significant effect on the advancement of all-fibre atomic force microscopy for biomechanical analysis and nanomanipulation in the future.
One of the few technologies that can carry out sensitive biomechanical studies is atomic force microscopy (AFM). The size and intricate feedback system of the bench-top AFM system are typical drawbacks, though.
Unfortunately, due to their size and intricate feedback mechanism, these instruments are constrained. create a tiny fibre optical nanomechanical probe (FONP) that can be utilised to test tissue in vivo and find out a cell’s mechanical properties.
By employing femtosecond laser two-photon polymerization nanolithography to design a microcantilever probe on the end face of a single-mode fibre, a FONP that can function in both air and liquids was created.
