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A thin film of silicone wrapped around a polycarbonate core allows for separation of the blood and gas phases in silicone oxygenators. These, on the other hand, were prone to tearing, resulting in mild bleeding and, in the worst-case scenario, sheet rupture.
PP MOs are microporous, hollow fibers that separate the patient’s blood from the circuit gas as it flows through the oxygenator. O 2 and CO 2 diffuse down concentration gradients via micropores with little direct contact between blood and gas. 3 The problem of plasma leakage with PP MOs is described in the literature.
This happens when blood plasma enters the gas part of the MO via the micropores, causing oxygenator failure, also known as foam out.
This issue prompts the creation of MOs made of PMP hollow fibers, which have practically prevented plasma leakage. Unlike PP MOs, which feature micropores that enable plasma and blood proteins to enter the gas phase of the MO over time, PMP MOs have a thin, tight membrane that offers full physical separation between the blood and gas phases, practically preventing plasma leakage.
The MO is involved in the majority of circuit problems that arise while on ECMO. The chief reasons for modifying the MO in those occurrences were oxygenator failure or oxygenator clot load.
Several great research on membrane oxygenators are now available in the literature. Two of the most prominent research studies compare silicone and PMP MOs in adults and newborns.
Furthermore, the first direct comparison This issue prompted the creation of MOs made of PMP hollow fibers, which have practically prevented plasma leakage.
Unlike PP MOs, which feature micropores that enable plasma and blood proteins to enter the gas phase of the MO over time, PMP MOs have a thin, tight membrane that offers full physical separation between the blood and gas phases, practically preventing plasma leakage.
Several great research on membrane oxygenators are now available in the literature. Two of the most prominent research studies compare silicone and PMP MOs in adults and newborns. Furthermore, the first direct comparison
The Global Hollow-Fiber Oxygenator Market accounted for $XX Billion in 2023 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2024 to 2030.
Inspira Technologies OXY B.H.N. Ltd., a company aiming to revolutionize acute respiratory care, announced today the development of the VORTX Blood Oxygenator, an Augmented Respiration Technology based on a new breakthrough technological approach, designed to mimic the function of the lung by efficiently saturating the blood with oxygen and removing carbon dioxide.
The VORTX Blood Oxygenator, which is currently in development, has the potential to revolutionize the perfusionists systems market, which is currently worth billion, with a target of million extracorporeal procedures performed annually, including open-heart surgeries and extracorporeal membrane oxygenation (ECMO) treatment.
The Company estimates that this market segment will increase significantly as a result of the extra market opportunity represented by the possible new treatment category offered by flagship INSPIRA ART.
The VORTX Blood Oxygenator is intended to increase hemodynamic performance while decreasing oxygenator failure. The present blood oxygenator market is based on hollow fiber membrane technology, which has been linked to medical issues such as device failure, coagulation (clotting), and hemolysis (damage or destruction of red blood cells), all of which pose dangers and have an influence on patient outcomes.
The VORTX Blood Oxygenator is being developed as a standalone disposable unit that will also work with the flagship INSPIRA ART system and ALICE device.
The VORTX Blood Oxygenator is scheduled to be submitted to the US Food and Drug Administration (FDA) for regulatory assessment and clearance after development and testing are completed.
The highly modern testing facilities of Inspira Technologies are at the heart of the creation of this product.
