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Indomethacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation.
It works by inhibiting the production of prostaglandins, endogenous signaling molecules known to cause these symptoms. It does this by inhibiting cyclooxygenase, an enzyme that catalyzes the production of prostaglandins.
In general, the adverse effects of Indomethacin are similar to those of all other NSAIDs. For instance, Indomethacin inhibits both cyclooxygenase-one and cyclooxygenase-two, which then inhibits the production of prostaglandins in the stomach and intestines responsible for maintaining the mucous lining of the gastrointestinal tract.
Indomethacin, therefore, like other non-selective COX inhibitors, can cause peptic ulcers. These ulcers can result in serious bleeding or perforation, requiring hospitalization of the patient.
To reduce the possibility of peptic ulcers, Indomethacin should be prescribed at the lowest dosage needed to achieve a therapeutic effect, usually between fifty and two hundred mg/day. It should always be taken with food.
Nearly all patients benefit from an ulcer protective drug (e.g. highly dosed antacids, ranitidine one hundred and fifty mg at bedtime, or omeprazole twenty mg at bedtime). Other common gastrointestinal complaints, including dyspepsia, heartburn and mild diarrhea are less serious and rarely require discontinuation of Indomethacin.
The Global Indomethacin market accounted for $XX Billion in 2023 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2024 to 2030.
Biocon Indomethacin – INDOMETHACIN belongs to the group of pain killers known as NSAID’s (Non-Steroidal Anti-Inflammatory Drugs) used to relieve symptoms caused by osteoarthritis, ankylosing spondylitis, and rheumatoid arthritis such as stiffness, swelling and joint pain.
INDOMETHACIN is also used to treat acute gouty arthritis, musculoskeletal pain, lower back pain, period pain, pain following joint and bone surgery.
INDOMETHACIN works by blocking the effect of a chemical messenger in the patient’s body, known as cyclo-oxygenase (COX) enzymes that make another chemical ‘prostaglandins’ (PG).
These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.
