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As an emerging field, nanofluidic devices offers unique phenomena compared to well-established microscale devices. Most importantly, it gives an opportunity to investigate molecules closely at the single molecule level.
Distinctive capabilities include stretching DNA to identify single sequence variations, optical mapping of the whole human genome, distinctive separation and electrophoresis phenomena to separate small biopolymers, and DNA/RNA sequencing.
Nanofluidic devices are often fabricated by etching tiny channels on silicon or a glass wafer and have potential applications in DNA sequencing, epigenetic analysis, gene therapy, drug delivery, and toxicity analysis.
Nanofluidic transistors and nanofluidic diodes are proposed to manipulate aqueous solutions and biomolecules at the nanoscale. The successful development of such systems has major implications for technologies focusing on water purification, processing of complex biological solutions, and energy conversion and storage.
Nanopores formed by proteins across biological membranes constitute a prominent example of nanofluidic phenomena, that is, ion flow through ion channels, in this range. While the development of artificial nanochannels with the same level of selectivity remains a challenge to be overcome, various modeling and experiments.
The Global Nanofluidic Devices market accounted for $XX Billion in 2022 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2023 to 2030.
Micro/Nanofluidic-Enabled Biomedical Devices: Integration of Structural Design and Manufacturing.
Micro/nanofluidic devices and systems have attracted ever-growing attention in healthcare applications over the past decades due to low-cost yet easy-customizable functions with the demand of only a small volume of sample fluid.
The continuous development, in particular, supported by the emergence of new materials, capable of meeting critical needs in next-generation, wearable, and multifunctional biomedical devices for at-home, personalized healthcare monitoring, is challenging the principles and strategies of structural design, manufacturing, and their seamless integration.
This summarizes the progress in micro/nanofluidic-enabled biomedical devices with a focus on structural design, manufacturing, and applications in healthcare.
Structures of fluidic channels and liquid actuation strength are given to elucidate the manipulations and controls of fluid transports that help capture desirable information of interest, including component separation, extraction, measurements, and disease diagnoses.
Manufacturing processes of fluidic devices in micro- and nanoscales and their basic working principles are also presented, ranging from lithography in traditional hard materials to 3D printing in emerging soft materials.
