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When target analytes are engulfed by particular antibodies or DNA probes mounted on the crystal chip surface, quartz crystal microbalances (QCM), which are piezoelectric biosensors, detect resonance frequency variation associated with mass change on the chip surface.
Another class of transducers that is utilised as a component of MIP-based biomimetic sensors are quartz crystal microbalances (QCMs). Many groups have used QCMs, which are shear-mode oscillators that are piezoelectrically activated, as a transducer for label-free biosensing.
A QCM typically comprises of an oscillation circuit and an electrode disc made of thin quartz with plated electrodes on both surfaces. The shift in the QCM’s oscillation frequency can be used to identify the binding of analytes to the device.
Since QCM is a mass sensitive transducer, it can identify chemical/biochemical species by their absorption without labelling.
Global quartz crystal microbalance (QCM) sensor market accounted for $XX Billion in 2022 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2023 to 2030.
The detection of vapours, volatile organic compounds (VOCs), environmental contaminants, biomolecules, illness biomarkers, cells, and pathogens in a variety of settings, including vacuum, has been one of the many other uses for QCMs in recent years.
High-frequency QCMs have recently made advancements that make it possible to measure the mass change in analytes adsorbed on customised QCM surfaces with pg/cm2 sensitivity.
In addition to numerous other analytical methods, QCM offers one of the most promising sensor technologies based on its low cost, quick response, portability, nonhazardous label-free real-time procedure, and high sensitivity.
This makes it perfect for the sensitive detection of analytes for next-generation sensors like chemical sensing, including electronic nose, electronic tongue, microfluidic devices, lab-on-a-chip, single molecule sensing, nanosensors, medical analyzers, and enzymes.
The number of QCM sensing applications has rapidly increased during the past few decades. In several deposition processes, including thermal vapour deposition, sputtering, and electrochemical deposition, they have been heavily utilised in deposition rate monitoring for managing thickness.
