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Tocolytic medication ritodrine (marketed under the name Yutopar) is used to prevent early labor. The FDA Orange Book reports that this medication has been taken off the US market.
It was typically used as the hydrochloride salt, ritodrine hydrochloride, and was either as oral tablets or as an injection.
Ritodrine is a short-acting 2 adrenoreceptor agonist, a type of drug used to relax smooth muscles (salbutamol (albuterol) and other similar medications are used to treat asthma and other pulmonary illnesses).
Ritodrine has a large N-substituent, which contributes to its high 2 selectivities. The 4-hydroxy group on the benzene ring is also crucial for activity since hydrogen bonds cannot be formed without it.
The 4-hydroxy group, however, makes it sensitive to catechol-O-methyl transferase metabolism (COMT). Since it is 2-selective, preterm labor is treated with it.
The majority of agonist-2 adverse effects, which include elevated heart rate, increased systolic pressure, decreased diastolic pressure, chest pain secondary to myocardial infarction, and arrhythmia, are brought on by their concurrent agonist-1 activity.
In addition to causing tachycardia and increased myocardial work, beta-agonists may also promote fluid retention as a result of decreased water clearance, which may lead to heart failure.
Additionally, they raise gluconeogenesis in the muscle and liver, which causes hyperglycemia and raises the need for insulin in diabetic patients. It is true that agonists cross the placenta, and this process may be to blame for fetal tachycardia as well as hypo- or hyperglycemia upon delivery.
Before getting treatment, patients with type 2 diabetes, hypertension, or migraines should inform their doctor about these conditions. Additionally, it has been linked to postpartum hemorrhage.
The Global RITODRINE market accounted for $XX Billion in 2023 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2024 to 2030.
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