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Utilising the correlation between a molecule’s molecular weight and size and the intensity of light it scatters, static light scattering (SLS) is a method for determining absolute molecular weight.
This method is mostly used to establish the size and molecular weight of molecules in solutions. The simplest form of it entails shining a laser beam into a material solution and measuring the photons that are scattered by the particles at different angles around the sample.
Static light scattering, as opposed to dynamic light scattering, yields a mean average intensity for the population by averaging the dispersed signal intensity across time.
If the equipment is properly calibrated, this information can also be utilised to calculate the molecular weight of the suspended particles.
The Global Static Light Scattering Detector market accounted for $XX Billion in 2022 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2023 to 2030.
For anyone evaluating the worth of a light scattering detector for gel permeation/size exclusion chromatography (GPC/SEC), Malvern Instruments has released “Static Light Scattering Technologies For GPC/SEC Explained.
“Within GPC/SEC detection systems, light scattering detectors are frequently utilised to identify the precise molecular mass, notably in the synthesis of polymer, protein, and macromolecular species.
Including Multiple Angle Light Scattering (MALS), Right Angle Light Scattering (RALS), and Low Angle Light Scattering, the new white paper from Malvern Instruments illustrates the differences between each light scattering technique used in GPC/SEC detection (LALS).
The practical applications of these various technologies and their unique benefits and drawbacks for various applications are a major focus.
Without the requirement for external calibration, static light scattering (SLS) is frequently employed to pinpoint the precise physical size or molecular weight of a molecule.
A selection of light scattering detectors are provided by Malvern. These can be used individually with any GPC/SEC system or combined with UV, viscometry, and refractive index detectors in an integrated triple or tetra detection Viscotek system for thorough characterization of polymers, proteins, and macromolecules.