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Enzymatic biosensors are analytical devices that contain an enzyme as a bioreceptor that is integrated or intimately associated with the physical transducer to produce a discrete or continuous digital electronic/optical signal proportional to the concentration of analyte present in the sample.
This signal can be caused by a change in proton concentration, the release or uptake of gases such as ammonia or oxygen, light emission, absorption or reflectance, heat emission, and so on, as a result of the enzyme-catalysed reaction.
Through electrochemical, thermal, or optical means, the transducer converts this signal into a measurable response, such as current, potential, temperature change, or light absorption. This signal can be amplified, processed, or saved for later use.
Glucose biosensors, mass-produced enzyme electrodes for diabetes patients’ rapid self-diagnosis of blood glucose levels, currently dominate the biosensor market.
The Global Enzymatic Biosensors Market accounted for $XX Billion in 2023 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2024 to 2030.
Maquet Critical Care, a global leader in hospital medical systems, recently set a new standard by launching the EIRUS platform, which was specifically designed to provide continuous monitoring of both lactate and glucose in critically ill patients.
In addition to improving patient care quality, it reduces nurses’ workload when compared to frequent intermittent blood analysis. This system is based on micro-dialysis technology, which feeds a flow-through sensor designed and manufactured by Jobst Technologies GmbH in Freiburg, Germany.
The present invention, in general, relates to reagent materials used to prepare sensors, such as enzyme-based electrochemical biosensors, sensors formed by them, and methods of fabricating and using them.
Because of the advancement of fixed technology and the characteristics of specific identification, enzyme biosensors have excellent application value when combined with point-of-care testing (POCT) technology.
POCT technology is gaining popularity as a highly effective method of clinic detection. This chapter summarises recent biosensor advances, focusing on the principle and classification of enzyme biosensors, immobilisation method of biorecognition layers, the fabrication of amperometric biosensors, and POCT applications.
There is also a summary of glucose biosensor development and integrated setups. The most recent applications of enzyme biosensors in diagnostic applications were described, with a focus on the POCT of biomarkers in real samples.
