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Fluorescence imaging is a type of non-invasive imaging technique that can help visualize biological processes taking place in a living organism. Images can be produced from a variety of methods including: microscopy, imaging probes, and spectroscopy. Fluorescence itself, is a form of luminescence that results from matter emitting light of a certain wavelength after absorbing electromagnetic radiation. Molecules that re-emit light upon absorption of light are called fluorophores.
Fluorescence imaging photographs fluorescent dyes and fluorescent proteins to mark molecular mechanisms and structures. It allows one to experimentally observe the dynamics of gene expression, protein expression, and molecular interactions in a living cell.[3] It essentially serves as a precise, quantitative tool regarding biochemical applications.
A common misconception, fluorescence differs from bioluminescence by how the proteins from each process produce light. Bioluminescence is a chemical process that involves enzymes breaking down a substrate to produce light. Fluorescence is the physical excitation of an electron, and subsequent return to emit light.
Fluorescent dyes, with no maturation time, offer higher photo stability and brightness in comparison to fluorescent proteins. In terms of brightness, luminosity is dependent on the fluorophores’ extinction coefficient or ability to absorb light, and its quantum efficiency or effectiveness at transforming absorbed light into fluorescently emitting luminescence. The dyes themselves are not very fluorescent, but when they bind to proteins, they become more easily detectable.
One example, Nano Orange, binds to the coating and hydrophobic regions of a protein while being immune to reducing agents. Regarding proteins, these molecules themselves will fluorescence when they absorb a specific incident light wavelength.
One example of this, green fluorescent protein (GFP), fluoresces green when exposed to light in the blue to UV range. Fluorescent proteins are excellent reporter molecules that can aid in localizing proteins, observing protein binding, and quantifying gene expression.
The Global Fluorescent imaging System market accounted for $XX Billion in 2022 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2023 to 2030.
Cyto SMART launches an advanced fluorescence live-cell imaging analysis system Omni FL – CytoSMART Technologies, an Axion Bio company, today announced the launch of the Cyto SMART Omni FL, a next-generation live-cell imaging analysis system incorporating red and green fluorescence channels into its signature CytoSMART Omni product line for the first time.
The advance reflects the company’s ongoing commitment to provide high-quality, accessible live-cell imaging to every cell biology lab and offers an innovative platform for researchers in stem cell biology, immuno-oncology, virology, toxicology, neurology, and other fields.
CytoSMART Technologies is a specialist in the development and manufacturing of live-cell imaging systems for life science laboratories. The company was founded in 2012 by a team of biologists and engineers who were convinced that a new generation of miniaturized microscopes, powered by artificial intelligence for image analysis, would allow biologists to make discoveries more efficiently and at scale.
In 2018, CytoSMART was selected by Microsoft for its prestigious ScaleUp program. CytoSMART’s microscopy solutions are used in research laboratories worldwide.
In 2022, Axion BioSystems, a US-based life sciences tools company focused on advanced live-cell assay systems, acquired CytoSMART Technologies. Both companies see large synergies to accelerate further growth together. CytoSMART Technologies is headquartered in Eindhoven, the Netherlands, and has more than 50 employees.
