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Due to its exceptional strength and randomly sized fibres, cellulose, a natural polymer, is a highly effective material for filtering. It acts as a versatile and extensive filtration method that works by encasing impurities and other particles in a web of fibres.
It is employed in routine laboratory filtration, such as when liquids need to be clarified or dry matter determined. There are pre-folded filters and circles of qualitative filter paper available. The substance used in cellulose (paper) filters is variable and unreliable.
The Global cellulose based automotive filter market accounted for $XX Billion in 2023 and is anticipated to reach $XX Billion by 2030, registering a CAGR of XX% from 2024 to 2030.
Such a development in technology has been made in the cellulose-based Seitz depth filter product line from Pall Life Sciences. To specifically meet the needs of the pharmaceutical industry’s present and future needs, the new Pall Stax single-use depth filter platform was developed.
Any large-scale filtering system must be able to work at commercial-scale production levels after scaling up from development trials, which is a crucial need. Process developers frequently use a safety margin of 30% or more for filtration area due to batch-to-batch variability and uncertainty in the scale-up performance of a filtering system.
A smart engineering practise is to allow for process variability, but doing so at the expense of the clarity step’s economics by doubling the filtration area based on a scale-up performance that is unknown. Pall took user friendliness and process considerations into account when creating a design idea for a sizable, single-use depth filter platform, resulting in a system design that relies on stacking depth-filter capsules vertically inside a chassis.
In order to facilitate installation, venting, and draining of the assembly as well as reduce the required footprint, this design was chosen over a horizontal layout.
The distribution manifold’s design allows for the process-scale chassis to be operated with the most freedom possible. The process flow goes through the distribution manifold at the bottom of the stack in a bottom in/bottom out configuration. It is possible for the process flow to enter and depart from opposite ends of the system by using the alternative operating mode of bottom in/top out or top in/bottom out.
